NSAID Risk

Drugs and Pooled Relative Risks of Cardiovascular Events


Drug    Pooled relative risks (95% CI)


Naproxen (Aleve 250-500 qd-bid) 1.09 (1.02–1.16)
Ibuprofen (Advil 200-800 mg/day)        1.18 (1.11–1.25)
Celecoxib (Celebrex 1-200mg qd) 1.17 (1.08–1.27)
Rofecoxib  (Vioxx)      1.45 (1.33–1.59)
Diclofenac (Voltaren)   1.40 (1.27–1.55)
Indomethacin (Indocin)  1.30 (1.19–1.41)
Piroxicam (Feldene 20 mg qd)    1.08 (0.91–1.30)
Meloxicam (Mobic)       1.20 (1.07–1.33)
Etodolac (Lodine)       1.55 (1.28–1.87)
Etoricoxib (Acroxia)    2.05 (1.45–2.88)
Valdecoxib (Bextra)     1.05 (0.81–1.36)

Naproxen was consistently shown to be safe, even at high doses

1.  McGettigan P, Henry D. Cardiovascular risk with nonsteroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies. PLoS Med 2011; DOI:10.1371/journal.pmed.1001098. 


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